A Bayesian Approach to Estimation and Testing in Time-course Microarray Experiments
نویسندگان
چکیده
منابع مشابه
A Bayesian approach to estimation and testing in time-course microarray experiments.
The objective of the present paper is to develop a truly functional Bayesian method specifically designed for time series microarray data. The method allows one to identify differentially expressed genes in a time-course microarray experiment, to rank them and to estimate their expression profiles. Each gene expression profile is modeled as an expansion over some orthonormal basis, where the co...
متن کاملBayesian approach to estimation and testing in time course microarray experiments
The objective of the paper is to develop a truly functional fully Bayesian method which allows to identify differentially expressed genes in a time-course microarray experiment. Each gene expression profile is modeled as an expansion over some orthonormal basis with coefficients and the number of basis functions estimated from the data. The proposed procedure deals successfully with various tec...
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In this paper we present a functional Bayesian method for detecting genes which are temporally differentially expressed between several conditions. We identify the nature of differential expression (e.g., gene is differentially expressed between the first and the second sample but is not differentially expressed between the second and the third) and subsequently we estimate gene expression temp...
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A truly functional Bayesianmethod for detecting temporally differentially expressed genes between two experimental conditions is presented. The method distinguishes between two biologically different set ups, one in which the two samples are interchangeable, and one in which the second sample is a modification of the first, i.e. the two samples are non-interchangeable. This distinction leads to...
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Characterizing the genome-wide dynamic regulation of gene expression is important and will be of much interest in the future. However, there is currently no established method for identifying differentially expressed genes in a time course study. Here we propose a significance method for analyzing time course microarray studies that can be applied to the typical types of comparisons and samplin...
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ژورنال
عنوان ژورنال: Statistical Applications in Genetics and Molecular Biology
سال: 2007
ISSN: 1544-6115,2194-6302
DOI: 10.2202/1544-6115.1299